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In C57BL/6 J mice, significant increases were observed in liver weight, lipid content, and ROS

For example, there are upper concentration limits when treating cardiac patients with these drugs who suffer from heart failure or arrhythmias 88

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There was no significant difference in the incidence of adverse events and serious adverse events in patients with diabetic neuropathy who took 600 mg/day of lipoic acid for four years compared to those in the placebo group (78)